A multivariate logistic regression analysis confirmed a significant association between increased tumor size [adjusted odds ratio (OR) and 95% confidence interval (CI), 2.27 (1.42–3.93), P = 0.024], the presence of lymphovascular invasion [adjusted OR and 95% CI, 8.43 (5.15–15.29), P < 0.001], and a Ki-67 index of >20% [adjusted OR and 95% CI, 1.91 (1.18–2.99), P = 0.038] and ALNM. The gene discussed is MKI67; the disease is neoplasm.