CDH1 and cancer: E-cadherin consists of a large extracellular domain composed of smaller transmembrane and cytoplasmic domains and 5 repeat domains.12 Overexpression of E-cadherin has often occurred in a number of human epithelial cancers.13 E-cadherin genes have been proven to be involved in oncogenesis and cancer development.14–16 A few studies had investigated the role of E-cadherin for lymph node metastasis in breast cancer, but the results were not consistent.