In wild type mice, ADR injection induced proteinuria, renal fibrosis, and increased macrophage infiltration into glomeruli (q-PCR and immnohistochemical staining of F4/80 in kidney sections) and increased production of pro-inflammatory cytokines (q-PCR for MCP-1, CD11c, TNF-α, and IL-1β). This evidence concerns the gene TNF and renal fibrosis.