Abs of healthy humans are inactive in the hydrolysis of DNA and MBP, while they possess low amylolytic activity Therefore, detection of abzymes with DNase-, MBP-hydrolyzing activities in combination with a significant increase in the oligosaccharide-hydrolyzing activity of Abs form sera and CSF of people can be considered as an additional criterion (immunological parameter) for early diagnostics of MS. This evidence concerns the gene MBP and myeloid sarcoma.