It has recently been shown that the specific reorganization of the immune system during spontaneous development of a profound SLE-like pathology in MRL-lpr/lpr mice [49–51] and MS-like pathology in experimental autoimmune encephalomyelitis mice [31] is associated with changes in the differentiation profile, the level of proliferation of bone marrow hematopoietic stem cells and the production of DNase, protease, ATPase, and amylase abzymes. This evidence concerns the gene DNAH8 and myeloid sarcoma.