When the two large groups of RP samples (benign RP-B and malignant RP-PCa) were compared with each other, most of the differences were statistically still highly significant (p≤0.001), except for RHOU, LMNB1 and PLA2G7, indicating the stronger impact of detectable cancer tissue on biomarker expression patterns compared to likely field effects. Here, LMNB1 is linked to posterior cortical atrophy.