CD8A and neoplasm: While we hypothesize that IFNγ secretion by tumor-antigen specific CD8+ T cells contribute to the survival benefit of preoperative IFNα treated mice, our data clearly suggest that other effector cells, possibly NK or dendritic cells, play an important role in mediating this process as preoperative IFNα administration did not impact cytokine secretion when CD8+ T cells were isolated (S4 Fig).