In this study, using an unbiased bioinformatics approach, we found that GC-resistant ALL cells exhibit significantly higher expression of all MAPK/ERK pathway components (RAS, RAF, MEK1/2, ERK1/2, JNK, cFOS), as compared to sensitive cells, indicating that GCs resistance in ALL cells might be driven by MAPK/ERK pathway signaling. Here, MAPK8 is linked to acute lymphoblastic leukemia.