Further studies have shown that miR-15a and miR-16-1 act as putative tumor suppressors by targeting BCL2, BMI1 CCND1, MCL1 and WNT3A in CLL, melanoma, as well as colon, bladder, ovarian and prostate cancers [4, 9, 10]. This evidence concerns the gene BCL2 and B-cell chronic lymphocytic leukemia.