Clinical components of MAS include prolonged fever, lymphadenomegaly, splenomegaly, hemorrhage, cytopenias that affect at least two leukocyte lineages, thrombocytopenia, hypoproteinemia, elevated liver enzymes, hemophagocytosis, tissue infiltration by activated macrophages, hyperferritinemia, and elevated soluble CD163 (sCD163) [51]. This evidence concerns the gene CD163 and hemorrhage.