This study found, using a pathway-oriented approach, that many pathways were altered in an overlapped manner between responders and non-responders but DNA replication, mismatch repair and TP53 signaling pathway were enriched in the non-responders We sequenced a small set of paired primary-metastatic tumors exposed long-term to hormonal blockade that experienced distant relapse, searching for novel genes involved in response/resistance to hormone treatments or accounting for disease relapse. This evidence concerns the gene TP53 and metastatic neoplasm.