Table 1 shows by case which genes were affected by severe alterations, and whether they were present in the primary/metastatic/both lesions. We found the K178N nucleotide change in NCOR1 in all cases. Another frequently mutated gene was KMT2C, which encodes for the histone lysine-specific methyl transferase 2C (a tumor suppressor in acute myeloid leukemia[29]). The D348N mutation was present in four pairs. According to the CGH arrays data, three regions (encoding, respectively, KDM5C, KDM6A and FOXO4) were gained in all but one pair (S2 Table). The gene discussed is KMT2C; the disease is acute myeloid leukemia.