By controlling the stability of protein kinases (PKA and Lats/Mob1), praja2 integrates signals carried out by two evolutionary conserved transduction cascades, having a major role in cell proliferation and tumor growth.28 Large-scale proteomic analyses revealed that praja2 is a component of a macromolecular complex that includes the ERK scaffold KSR1.31 Based on this finding, we tested whether praja2 interacts with and regulates the stability KSR1. This evidence concerns the gene KSR1 and neoplasm.