LGR5 and rectal cancer: In addition to the small intestine, Lgr5+ stem cells have also been found in the hair follicles,24, 25 the stomach,26 the colon,8 colon cancer27, 28, 29 and rectal cancer.29 Thus, the behavior of these stem cells following chemotherapy may be similar in these tissues and contribute to the study of the chemotherapy-related side effects, including alopecia, vomiting and anorexia.