β-arr1 is involved in maintaining cellular homeostasis9 and has an important role in the pathogenesis of various diseases, including sepsis,10 cerebral ischemia11 and asthma.12 Based on a previous study, β-arr1 facilitated Akt-mediated activation of MDM2 (human murine double minute 2, the E3 ligase for p53) and also promoted MDM2 binding to, and degradation of, p53 by acting as a molecular scaffold.13 Based on these results, we hypothesized that inhibition of β-arr1 may aggravate chemotherapy-induced apoptosis via activation of p53. Here, MDM2 is linked to Sepsis.