In this study, it was demonstrated that linc-UFC1 was overexpressed in CRC tissues compared with adjacent non-tumor tissues and was positively correlated with the tumor histology grade, N grade and M grade, suggesting linc-UFC1 as a useful diagnostic biomarker or therapeutic target in CRC.20 The role of linc-UFC1 in CRC was further investigated by detecting the alterations of biological behaviors in CRC cell lines after linc-UFC1 knockdown. The gene discussed is UFC1; the disease is colorectal carcinoma.