UFC1 and cancer: Various factors may affect apoptosis of cancer cells through different signaling pathways.31, 32 P38, as a serine–threonine kinase and a key member of the MAPK pathway, has an important role in a variety of physiological and pathological processes, including cell death or apoptosis.33, 34 In this study, linc-UFC1 downregulation modulated the phosphorylation level of P38 and exerted its influence on apoptosis in CRC cells.