Our findings are consistent with the idea that the knockdown of linc-UFC1 by shRNAs induced apoptosis of CRC cells by the activation of caspase-9 and caspase-3, indicating that linc-UFC1 inhibition could enhance the chemosensitivity of CRC cells and that linc-UFC1 might be an attractive therapeutic target in CRC treatment. Here, CASP3 is linked to colorectal carcinoma.