TP63 and EEC syndrome: Several methods to modulate gene expression have been developed, including gene editing by zinc-finger nuclease (TALEN, CRISPR/Cas) and modification of the transcripts by exon skipping, and protein inhibitors by antibodies and drugs.25, 26, 27 Among these methods, we believe that allele-specific knockdown could be a highly relevant therapeutic method for EEC syndrome, and possibly other ED disorders, because the mutated-p63 protein form a high order complex with WT p63 protein (tetramerization), therefore showing the dominant-negative effect.