MTOR and cancer: CPTI serves to activate FAO that increases ATP and NADPH reserves, protecting cancer against the environmental stress such as glucose deprivation and hypoxia.60, 61 CTP1C expression displays an inverse correlation with the activation of mTOR pathway and attenuates tumor sensitivity to rapamycin (a mTOR inhibitor),18 which suggests that the CPTIC-involved pathway parallels to mTOR-enhanced glycolysis.62 Moreover, CPTIC is an essential downstream mediator of the AMPK pathway as well as a target gene of p53 in a p53/AMPK-dependent manner.39