TP53 and cancer: And LCAD loss further promotes cancer by reduction of PTEN, highlighting the significance of FAO inhibition in cancer.38 However, in lung cancer and breast cancer, tumor cells constitutively expressing CPTIC show increased FAO, ATP production and resistance to hypoxia.18 Further study shows that CPTIC is induced by AMPK activation under hypoxia and a p53–AMPK–CPTIC axis evoked in response to metabolic stress has also been implicated.18, 39