LATS2 is a important member of the large tumor-suppressor family, which has been identified as a new regulator of cellular homeostasis.33 Importantly, the missed expression of LATS2 has been found in multiple human cancers including NSCLC, and our results also revealed that upregulated its levels inhibited NSCLC cells growth and induced apoptosis. This evidence concerns the gene LATS2 and cancer.