It is clear that lncRNAs regulate target expression through various mechanisms, such as recruiting chromatin-modifying enzymes to target genes and regulating their transcription either in cis or in trans, serving as scaffolds for bind relevant molecular components or function as competing endogenous RNAs by binding with miRNA response elements to release miRNA regulation of their targets.13, 15, 27 In this study, we found that AGAP2-AS1 could bind with EZH2 and LSD1, and recruit them to LATS2 and KLF2 promoter regions to repress their transcription in NSCLC cells. This evidence concerns the gene KLF2 and non-small cell lung carcinoma.