Our previous studies revealed that P53-regulated lncRNA TUG1 affects cell proliferation through interacting with enhancer of zeste homolog 2 (EZH2) and epigenetically regulating HOXB7 expression in NSCLC cells.21 Moreover, overexpression of ANRIL exerts oncogenic function through promoting NSCLC cells proliferation via recruiting EZH2 to KLF2 and P21 promoter regions and repressing their transcription.22 In this study, we identified an new lncRNA-AGAP2-AS1, which is located in chromosome 12q14.1 and 1567 nt in length. The gene discussed is KLF2; the disease is non-small cell lung carcinoma.