Furthermore, we chose several EZH2 or LSD1 potential targets (P15, P21, LATS1, LATS2, RND1, KLF2, E-cadherin, PTEN, ASPP2 and RRAD) with tumor-suppressor function, and hypothesized that they may involve in the contributions of AGAP2-AS1 to NSCLC progression. Here, TP53BP2 is linked to non-small cell lung carcinoma.