LEPR and type 2 diabetes mellitus: We observed a significant increase in RCAN1.1 and RCAN1.4 protein (Fig 2H) in islets from the leptin receptor deficient T2D mouse model, db/db (12 week old males, db/+ weight = 22.5 ± 1.1 g, plasma glucose = 8.5 ± 0.3 mM, db/db weight = 46.6 ± 1.1 g, plasma glucose = 24.1 ± 1.4 mM).