ANXA5 and lip and oral cavity carcinoma: In current study, we provided evidence for the apoptosis effect of URH in oral cancer Ca9-22 cells, such as sub-G1 accumulation and annexin V/PI staining (Figures 3 and 4), which were coupled with high ROS, superoxide generations, and mitochondrial depolarization; that is, the correlation values (R2) are 0.8435, 0.6294, and 0.6782 for ROS (+), mitoSOX (+), and MMP (−) versus apoptosis (annexin V (+)), respectively, although the effect of lower doses of URH was not examined in our study.