Skeletal muscle of ALS patients shows a reduction in mRNA levels of satellite cell and early myogenic markers PAX7 and MYF5 compared to controls, whereas the mRNA levels of the late myogenic markers myogenin (MYOG) and MYOD1 are increased (Figures 4(a)–4(d)). The gene discussed is MYF5; the disease is amyotrophic lateral sclerosis.