PLG p.T200A seems of particular interest, as it was identified in eight MS patients and no controls (Table 2), it is evolutionary conserved (Figure 2), and a threonine to proline substitution at the same position has been identified in a patient with severe type I PLG deficiency (Tefs et al. 2006). The gene discussed is PLG; the disease is hyperinsulinemic hypoglycemia, familial, 4.