Synthetic inhibitors of MMPs have been found to ameliorate clinical symptoms and pathological signs in experimental autoimmune encephalomyelitis (EAE) animal models (Cuzner and Opdenakker 1999); minocycline, which has several immunomodulating activities including the inhibition of MMP-9, has been used successfully in clinical trials as an add-on therapy for MS patients (Metz et al. 2009). The gene discussed is MMP9; the disease is experimental autoimmune encephalomyelitis.