NUCLEOLIN and cancer: AS1411 targets nucleolin, an abundant multifunctional 110 kDa phosphoprotein15 and one of the major nucleolar proteins that functions as a shuttle protein between the nucleus and cytoplasm; it is also found on the many kinds of cancer cells surface where it acts as a binding protein for a variety of ligands implicated in cellular proliferation, differentiation, adhesion, mitogenesis and angiogenesis.