TFBS analysis suggests that several TFs, such as p53, E2F and AP2, were activated by BI-2536/fasudil, and that most of the DEGs that are targets of these activated TFs, which is related to disease genes in lung cancer (green) and non-small cell lung cancer (NSCLC; blue) according to the MalaCards database (Fig. 3c). This evidence concerns the gene TP53 and lung cancer.