IL6 and Hyponatremia: Our study firstly demonstrated the association of hyponatremia with the decreased C3 and increased ESR levels and SLEDAI which reflect disease activity of SLE in a cohort of children with SLE and serum sodium levels were correlated negatively with serum IL-6 levels in an independent cohort of adults with SLE, which have not been investigated in both adults and children over the past decade.