CRP and schizophrenia: On the other hand, when we calculated the effect of the CRP levels on the risk of schizophrenia in the world-wide population by combining 2 pooled estimates, OR of schizophrenia from a meta-analysis of GWAS43 and beta of CRP from a meta-analysis of GWAS31, we found a significant effect of CRP levels on schizophrenia, representing an ORscz/cro of 1.15 (95% CI, 1.00–1.31; p = 0.046) using rs2794526 and 1.21 (95% CI, 1.04–1.40; p = 0.014) using rs1183910, as well as an ORscz/cro of 1.17 (95% CI, 1.06–1.30; p = 0.0017) across these 2 SNPs (Fig. 3).