In this study, we revealed the presence of higher serum CRP levels in patients with schizophrenia compared to controls in the Japanese population by conducting an ANCOVA with separate genotypes of the 2 SNPs (rs2794520 and rs1183910) identified in the meta-analyses of genome-wide association studies of CRP although the difference between 2 groups in the stratum of rs2794520 CC genotype did not reach statistical significance after the Bonferroni adjustment. Here, CRP is linked to schizophrenia.