GRN and infantile neuronal ceroid lipofuscinosis: Interestingly, a GRN loss-of-function, caused by a homozygous 4-bp deletion in the GRN gene has been associated with NCL11, a form of neuronal ceroid lipofuscinosis, in which the lysosomal storage disorder coexists with the accumulation of phosphorylated TDP-43 in neurons.