NPC1 and nasopharyngeal carcinoma: In order to correlate the results obtained both in the NPC mouse and in the neuronal model of the disease, the expression and localization of TDP-43 was analyzed in brain tissue obtained from a NPC patient carrying mutations c.2621A > T (D874V) and IVS14-2A > G in the NPC1 gene (Additional file 3: Figure S2).