IFNG and colitis: To assess the contribution of IL-23 signalling to the development of intestinal inflammation and differentiation of IL-17A+IFN-γ+ T cells in a lymphocyte replete setting, we induced colitis by oral infection with Helicobacter hepaticus (Hh) and concomitant administration of IL-10R blocking antibody (Hh+anti-IL-10R)9.