As expected, AQP4 expression decreased in the NMO-rats whereas AQP4-IgG depletion partially prevented such a decrease, as shown by immunodetection (Fig. 8a) and signal quantification (Fig. 8d, NMO-ratsAQP4+dep versus NMO-rats, p = 0.0001) In parallel, IgGAQP4+dep induced less myelin disorganization and MBP decrease (Fig. 8b, d) than IgGAQP4+ (p = 0.001) but has less on effect on axonal loss (Fig. 8c, d). The gene discussed is MBP; the disease is neuromyelitis optica.