In accordance with previous studies, in the present study, we also found that ectopic CTNND1 remarkably increased the level of β-catenin, WNT11, Cyclin D1, and MMP7 at both the protein and mRNA level, whereas silencing CTNND1 robustly suppressed β-catenin, Wnt11, Cyclin D1, and MMP7 expression in HCC cells. Here, CTNND1 is linked to hepatocellular carcinoma.