To determine whether any correlation existed between CTNND1 expression and the representative markers of Wnt/β-catenin signaling in HCC biopsy samples, we obtained RNA from 26 HCC samples and analyzed CTNND1, β-catenin, WNT11, Cyclin D1, and MMP7 expression using real-time RT-PCR. The gene discussed is CCND1; the disease is hepatocellular carcinoma.