Furthermore, gene-set enrichment analysis indicated that gene signatures related to proliferation, neoplasm metastasis and invasion, cell movement and motility, and Wnt/β-catenin signaling were significantly changed in CTNND1-silenced cells (Fig. 7b), supporting the idea that CTNND1 regulates proliferation, EMT, and cancer invasion and metastasis. Here, CTNND1 is linked to cancer.