We evaluated the mRNA expression of Wnt2, -4, -5a and -7b ligands; Fz1, -2, -3, -4, -5, -8, Ror2 and Ryk receptors; and the Wif1 secreted inhibitor in both WT and ALS transgenic mice. Here, FZD1 is linked to amyotrophic lateral sclerosis.