Definition of the drug therapy evaluated: the drug therapy evaluated was related toreduction in CHD's morbidity and mortality - lifesaving therapy - (that is,ACE-inhibitors, ARBs, Beta blockers, antiplatelet drugs and statins) and two otherdrugs which improve the signs and symptoms associated with coronary heart disease(that is to say, digitalis, diuretics and nitrates). This evidence concerns the gene ACE and coronary artery disorder.