Candidate neoantigens were identified based on the following criteria: 1) the mutation being present in the tumor but not in matched normal tissue (Fig 7a); 2) at least one read from RNA-seq data supporting expression of the mutated allele (Fig 7b); and 3) a predicted MHCI binding score of < 100 nM for at least one of the autologous HLA-A alleles (Fig 7c). This evidence concerns the gene HLA-A and neoplasm.