These are 53 families carryingBRCA1/BRCA2 germline mutation, 33 with a mutationin Lynch-related genes, 30 TP53 mutated, 44 with germline mutations inthe APC gene, six with MUTYH associated polyposis,five with VHL mutations, two with MEN2A and one with HDGC. This evidence concerns the gene VHL and polyposis.