FGFR4 and breast carcinoma: To better understand the role of aberrant kinase signaling and identify bona fide molecular targets for drug development in basal-like breast cancers, we undertook a large-scale loss-of-function shRNA screen of the kinome, leading to the identification of fibroblast growth factor receptor 4 (FGFR4) as an essential kinase critical for the proliferation and survival of basal-like breast cancer cells.