FGFR4 and squamous cell lung carcinoma: We hypothesized that the constitutive activation of FGFR4 in MDA-MB-468 and HCC1937 could be mediated by an autocrine secretion of FGF19 as has been shown in other cancers, such as hepatocellular carcinomas, lung squamous cell carcinomas, and colon adenocarcinomas [41–43].