We analyzed the correlation of WDR5 expression with that of its targets in the cohort study of ALL and AML patients, and observed a positive correlation of WDR5 expression with that of Lyn (Supplementary Figure S4A and S4B), MED24 (Supplementary Figure S4C and S4D), RBM22 (Supplementary Figure S4E and S4F), which are important for oncogenesis and apoptosis. This evidence concerns the gene RBM22 and acute lymphoblastic leukemia.