Our data first showed the WDR5 high expression particularly the WDR5high+MLL1high expression in leukemia patients and their correlations with high-risk ALL and AML leukemia; and revealed the oncogenic effects of high WDR5 expression in acute leukemia by activation of its oncogenic targets via epigenomic regulation, as shown on a model of Supplementary Figure S7. This evidence concerns the gene WDR5 and acute lymphoblastic leukemia.