KMT2A and leukemia: Patients with high expression of WDR5 have higher percentage of CD20+ cells (60.0% vs 0.0%, P = 0.001), Philadelphia chromosome (Ph) (+)(34.4% vs 0.0%, P = 0.026), higher MLL1 expressions (66.7% vs 13.3%, P = 0.000), splenomegaly and liver infiltration (72.4% vs 20.0%, P = 0.001; 51.7% vs 13.3%, P = 0.013), and leukemia blast in bone marrow (BM) (87.6% vs 72.4%, P = 0.022) compared to patients with low WDR5 expression (Figure 1B, 1C and 1D; Supplementary Table S1).