Then, we further observed the enrichment of H3K4me3 in the promoter region of WDR5 targets and found that H3K4me3 is dramatically enriched in the promoter region of Lyn, BCL9, RAB28, CD93, MED24, and RBM22 in Nalm6 (Figure 5C) and U937 (Figure 5D) cells as well as primary B-ALL (Figure 5E) and AML (Figure 5F) cells. Here, RBM22 is linked to precursor B-cell acute lymphoblastic leukemia.