In order to obtain insight into the potential functional impact of EZH2 in CLL, we subdivided CLL cases based on the mRNA expression levels into EZH2high and EZH2low subgroups and found that the former displayed higher H3K27me3 levels, supporting an association between EZH2 expression and enzymatic activity. The gene discussed is EZH2; the disease is B-cell chronic lymphocytic leukemia.