TP53 and plasma cell myeloma: [25, 32] Indeed, Iannetti et al [33] showed that CLL cell stimulation with the CD40 ligand, which strongly induces the alternative NF-κB pathway, also induces EZH2 expression, leading to suppression of a subset of p53 target genes previously associated with the senescent cell phenotype, including DEK and RacGAP1. Furthermore, c-Rel was also recently found to be a critical activator of EZH2 transcription in activated primary murine B and T cells, and also in human leukemia and multiple myeloma cell lines.