As a control we performed the same analysis for two EZH2low cases, with a different pattern emerged depending on SHM status: in particular, the M-CLL/EZH2low case analyzed was negative for Ki67+ cells (Figure 5F), while in the U-CLL/EZH2low case, though few Ki67+ cells were detected, 62% of these co-expressed EZH2. Here, MKI67 is linked to B-cell chronic lymphocytic leukemia.