Notably, however, an inverse correlation was noted between EZH2 expression levels and TP53 gene abnormalities (TP53abn: del(17p) and/or TP53 mutations) amongst U-CLL, in that U-CLL/EZH2high cases harbored significantly fewer (p = 0.033) TP53abn (2/27 cases, 7%) compared to U-CLL/EZH2low cases (6/19, 32%). Here, TP53 is linked to B-cell chronic lymphocytic leukemia.