We also show that EZH2 expression is associated with CLL cell proliferation as well as resistance to apoptosis, while downregulation of EZH2 expression or pharmacological inhibition of EZH2 catalytic activity leads to apoptosis, highlighting a crucial role for EZH2 in CLL cell homeostasis. The gene discussed is EZH2; the disease is B-cell chronic lymphocytic leukemia.