EZH2 and B-cell chronic lymphocytic leukemia: Moreover, we reported that EZH2 expression is modulated by miR-101, a well known epi-miRNA, which was downregulated in CLL subset #1 [15] since changes in miR-101 expression brought about by silencing using miR-101 inhibitor or overexpression using miR-101 mimic affected EZH2 protein expression in primary CLL cells [15].