RBBP4 and cancer: [23] On these grounds and also considering that many of these epigenetic enzymes are deregulated in various types of cancers [35], we also profiled their expression using PCR arrays and found that the main PRC2 components SUZ12, EED, EZH1, RBBP4 and RBBP7 are expressed in CLL cells in a fashion concordant to that of EZH2, hence being available for assembling functional complexes with the overexpressed EZH2.