Moreover, overexpression of either the CREB wild type cDNA or constitutively active mutant CREB-Y134F cDNA increased the expression of NE markers and GRK3 in prostate cancer cells (Figure 3C, 3D, 4A, Supplementary Figure S1, Supplementary Figure S3A). The gene discussed is GRK3; the disease is Familial prostate cancer.