LYL1 and acute lymphoblastic leukemia: The Gene Set Enrichment Analysis (GSEA) [34] analysis revealed a marked enrichment of the TLX1+ gene signature (cortical mature T-ALL) in low TRIB2 expressing T-ALL patients (Fig 7A, 7B, 7E and 7F), whereas the gene signature of LYL1+ (early immature T-ALL) significantly associated with samples expressing high levels of TRIB2 (Fig 7A, 7C, 7E and 7G).