It remains unknown regarding the precise role of TRPV4 in mouse and human atherosclerosis and whether endothelial function and atherosclerosis development will be exaggerated in TRPV4−/−; ApoE−/− mice, or in ApoE−/− mice treated with the TRPV4 inhibitor GSK2193874. The gene discussed is TRPV4; the disease is atherosclerosis.