Still, whole-exome sequencing studies did reveal somatic SETD2 mutations in various types of cancer (Table 2), and this can be seen as an indication that SETD2 inactivation plays a role in the development of other tumors, albeit with low frequencies in most of them (COSMIC [96], Tumorportal [97] and cBIOPortal [98, 99], accessed in January 2016). This evidence concerns the gene SETD2 and cancer.