SETD2 and cancer: In the TCGA, SETD2 mutations were found to be associated with worse cancer-specific survival (P = 0.036; HR 1.68; 95% CI 1.04-2.73), and the presence of SETD2 mutations was a predictor of ccRCC recurrence in an univariant analysis (P = 0.002; HR 2.5; 95% CI 1.38-4.5) [107].