To identify the host and parasite factors involved in this process, we embarked on a study to elucidate the fate of endosomal SNAREs during infection of macrophages with L. mexicana. Given the requirement of CPB for L. mexicana to replicate normally inside macrophages [19], we included a L. mexicana CPB-deficient mutant (Δcpb) in our investigation. Here, CPB1 is linked to infection.