Heparanase, which is an endoglycosidase that cleaves heparan sulfate (HS) glycosaminoglycans, can also guide cancer-promoting action of TAM by augmenting STAT3 signaling in vitro and in a mouse model of heparanase-overexpressing pancreatic carcinoma [64]. Here, HPSE is linked to exocrine pancreatic carcinoma.