In pancreatic cancer, inhibition of macrophage recruitment by targeting either the CSF-1 receptor (CSF-1R) (PLX6134, PLX3397) or CCR-2 (PF-04136309) resulted in a significant reduction of pancreatic cancer cells expressing high levels of the CSC marker ALDH [124]. This evidence concerns the gene CCR2 and familial pancreatic carcinoma.