In addition, TGF-α, which secreted by the tumor cells and the MDSC population, has immunosuppressive properties that include inhibition of T cell activation, proliferation and differentiation into CTL or Th cell subsets, as well as drives the development of FoxP3+, CD4+, CD25+ Treg which suppress antitumor immunity [110, 111]. This evidence concerns the gene TGFA and neoplasm.