In addition, CXCL8/IL-8 and CXCL12/stromal cell-derived factor-1α (SDF-1α) can co-operatively promote migration/invasion and angiogenesis in pancreatic cancer, [132] indicating that CXCR2 and CXCR4, corresponding receptors for CXCL8 and CXCL12 respectively, are potential anti-angiogenic and anti-metastatic therapeutic targets in pancreatic cancer. This evidence concerns the gene CXCR4 and familial pancreatic carcinoma.