Pancreatic cancer cell lines (PANC-1 and BxPC-3) co-cultured with M2-polarized TAM could upregulate mesenchymal markers vimentin and Snail at the mRNA and protein levels, augment the proteolytic activity of metalloproteinases MMP-2 and MMP-9, and decrease the expression of the epithelial marker E-cadherin [116]. This evidence concerns the gene SNAI1 and familial pancreatic carcinoma.