GSK3B and posterior cortical atrophy: Our observed that CAPE treatment reduced activity of MMP-9 as well as abundance of MMP-9, vimentin, Snail, and phosphorylation of GSK-3β but elevated epithelial marker of E-Cadherin and GSK-3β, suggesting that CAPE treatment suppressed PCa metastasis via inhibition of Wnt signaling and EMT (Figures 2–5).