We previously reported that CAPE dose-dependently suppressed the proliferation of both androgen-dependent and CRPC PCa cells via induction of cell cycle arrest, inhibition of c-Myc, Akt, and Skp2, as well as activation of p21Cip1, p27Kip1, and p53 [6–8]. This evidence concerns the gene AKT1 and posterior cortical atrophy.