Because we recently described that fast engrafting T-ALL exhibit enhanced NF-κB pathway activation [12], it might be interesting to look into this activation in the CD7+/CD34+ and CD7+/CD34− sub-fractions, also because NF-κB pathway is activated following extracellular signals, such as those provided by inflammation, and we have previously shown that the pro-inflammatory cytokine IL-18, that activates NF-κB, participates into T-ALL development [20]. The gene discussed is CD34; the disease is acute lymphoblastic leukemia.