TRPV1 and Sepsis: In addition, there is evidence that gastrointestinalinflammation causes hyperalgesia at least in part by the upregulation and sensitizationof TRPV1 (28), and that TRPV1 desensitizationchanges the release of TNF-α during sepsis (80).However, the induction of a pro-inflammatory response after the activation of the TRPV1channel is not a universal finding (49).