BRAF and melanoma: The Cancer Genome Atlas (TCGA) melanoma skin cancer study investigated exome sequences of 333 melanomas [8], and revealed recurrent aberrant sequence variants in a number of genes, including BRAF, NRAS, TP53, PPP6C, NF1, CDKN2A, PTEN, ARID2, DDX3X, RAC1, IDH1, RB1, MAP2K1, HRAS, KRAS, KIT, and CDK4.