In contrast, 5.6% (26/466) of melanoma samples contained an EPHB6G404S mutation, and when divided between North and South Islands, 7.8% (26/333) of North Island melanoma samples contained an EPHB6G404S mutation, making this the third most commonly mutated protein-coding gene after BRAF and NRAS. Remarkably, all 26 EPHB6G404S mutation were observed in North Island melanomas, and EPHB6G404S mutations were not identified in South Island melanomas (P=0.0002). This evidence concerns the gene BRAF and melanoma.