The miR-15a/16-1 cluster at 13q14.3 is frequently deleted in B-cell chronic lymphocytic leukemia (B-CLL) [10], and miR-15a and miR-16-1 are bona fide tumor suppressors, which act by targeting oncogene Bcl-2 [11]. Here, BCL2 is linked to B-cell chronic lymphocytic leukemia.