Except for rs700926 in NPR-C, none of the 12 SNPs being validated (HFE: rs2071303, rs2794719; CAT: rs554576, rs524154, rs7947841; HOMX1: rs2071749; CXCL9: rs2276886, rs2869460; PON3: rs2057682, rs7787187, rs11977702) showed significant association with CAD in Val-Shandong and Val-Hubei cohorts (Supplementary Table S.3), and thus these 12 SNPs did not undergo further analysis. Here, NPR3 is linked to coronary artery disorder.