NPR3 and coronary artery disorder: To assess whether common variants in the NPR-C gene were associated with sporadic CAD in the Chinese population, 9 tag SNPs of NPR-C (rs1833529, rs2270915, rs17541471, rs3792758, rs696831, rs7715279, rs6450922, rs10941022 and rs976576) were firstly genotyped by the Shandong research group in 4 cohorts from Northern (Rep-Shandong and Rep-Shaanxi) and Southern (Rep-Hubei and Rep-Sichuan) China, respectively (Supplementary Figure S.3).