Of them, only rs12697273 and rs10066436 of NPR-C showed a consistent association with CAD in these two cohorts (Table 4), and these associations remained significant even after adjustment for the statistically significant covariates of age, gender, hypertension, diabetes, smoking, total cholesterol, triglyceride, high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C). The gene discussed is NPR3; the disease is hypertensive disorder.