To further test their potential association with CAD in a larger population, 13 tag SNPs (rs2071303 and rs2794719 in HFE; rs554576, rs524154 and rs7947841 in CAT; rs2071749 in HOMX1; rs2276886 and rs2869460 in CXCL9; rs2057682, rs7787187 and rs11977702 in PON3; rs6568719 in LAMA4; rs700926 in NPR-C) that have relatively strong representativeness for these 7 genomic regions, respectively, were selected from the HapMap database and considered for genotyping analysis in the two independent validation populations from Northern (Val-Shandong Cohort) and Southern (Val-Hubei Cohort) China. The gene discussed is NPR3; the disease is coronary artery disorder.