For stratified analysis by ethnicity, the APC methylation showed statistically significant association with increased risks of breast cancers in Caucasians (OR = 3.08, 95% CI = 1.92–4.96, P < 0.00001) and in non-Caucasians (OR = 18.75, 95% CI = 4.12–85.28, P < 0.00001). This evidence concerns the gene APC and breast cancer.