APC and breast cancer: In analyses of ER, PR and HER-2, we demonstrated that there was an association between APC promoter methylation and ER (pooled OR = 1.34, 95% CI: 1.03–1.73, P = 0.03, Figure 7), inversely there was no relationship between APC methylation and breast cancer with PR+ (pooled OR = 0.91, 95% CI: 0.71–1.18, P = 0.49, Figure 8) and Her-2+ (pooled OR = 0.79, 95% CI: 0.44–1.40, P = 0.42, Figure 9), which was in consistent with the previous study by Sunami et al. [34].