Consistently, we examined the change of invasive and migratory abilities in C4-2B and CW22Rv1 cells with AR knockdown and DANCR knockdown, and found that AR knockdown promoted invasion and migration of prostate cancer cells and DANCR knockdown decreased the promotion of cell invasion and migration by AR down- regulation (Figure 6I and 6J). This evidence concerns the gene AR and Familial prostate cancer.