Our results showed that the combined inhibition of WNT5A signalling (Box5) and IL-6 signalling (neutralising anti-IL-6 antibody) mimicked the results of the combined siRNA knockdown of WNT5A and IL-6 by more effectively reducing the migration and invasion of two different invasive melanoma cell lines, compared with the results from individual treatments with either Box5 or a neutralising anti-IL-6 antibody. Here, WNT5A is linked to melanoma.