In this regard, preliminary data in our lab indicates that this gelatinase/type IV collagenase, like MMP-8, was also increased by diabetes and that CMC2.24 treatment suppresses this excessive MMP during wound-healing—a similar pattern of change for this gelatinase was recently seen by us during experimental diabetes and its treatment with CMC2.24 in gingiva and skin [32]. The gene discussed is MMP8; the disease is diabetes mellitus.