MMP8 and diabetes mellitus: In this regard, MMP-8, which in the current study was generated in dramatically elevated levels during diabetes in the early inflammatory phase of wound-healing, was significantly reduced by CMC2.24 treatment; it is important to note that both MMP-8 (collagenase-2) and MMP-9 (gelatinase B) are released when polymorphonuclear leukocytes degranulate during the inflammatory response.